2024 Trimethyltin and cancer

Trimethyltin and cancer

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August undefined, 2024

WebTrimethyltin (TMT), a toxic organotin compound, induces neurodegeneration selectively involving the limbic system and especially prominent in the hippocampus. … WebApr 11, 2024 · Ginsenoside compound K has been proven to have a range of anti-cancer activities against lung cancer, leukemia, breast cancer, and colon cancer [8,9,10,11]. Ginsenoside Rh2 shows anti-cancer activity against lung cancer and liver cancer by mediating the apoptosis of cancer cells and suppressing cell proliferation and migration [ …

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WebA series of triorganotins, (trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT)) have been shown to decrease the lytic function of human NK cells. TPT and MDPT were much more effective than DMPT or TMT at reducing lytic … WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. Like many other ototoxicants, it preferentially affects the outer hair cells of the basal (high-frequency) areas of the cochlea. Electrophysiological changes in the compound action potential can be detected within minutes. meigs county tn assessor

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WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy. WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy. WebTrimethyltin and methyl mercury are both neurotoxicants that also have ototoxic properties. Of note is the fact that the chemically related triethyltin is a neurotoxicant but not an … meigs county tn arrest report

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WebOct 6, 2024 · Chemotherapy as the primary treatment for advanced breast cancer. If breast cancer has spread to other parts of your body and surgery isn't an option, chemotherapy … WebMar 1, 2024 · Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Yuqi Wang, Xiaojing Liu, Hongyuan Jing, ... PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling. Ying Bai, M. Ludescher, +13 authors H. Neubauer ... meigs county title officeWebTrimethyltin (TMT) is an organotin compound exhibiting neurotoxicant effects selectively localized in the limbic system and especially marked in the hippocampus, in both experimental animal models and accidentally exposed humans. TMT administration causes selective neuronal death involving either the granular neurons of the dentate gyrus or the … nantwich fair

"WebTrimethyltin (TMT) is an environmental neurotoxin that mediates dopaminergic neuronal injury in the brain. In this study, we characterized the toxic mechanism and possible protective compounds against TMT-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells. Antioxidants such as melatonin, N-acetylcysteine (NAC), α … " - Trimethyltin and cancer

Trimethyltin and cancer

WebTrimethyltin is an intermediate by-product in the production of other more commonly used tin products. 3 It, ... Case Study 39: Residential Radon Exposure and Lung Cancer in Sweden 695–700; Case Study 40: Community Oubreaks of Asthma Associated with Inhalation of Soybean Dust 701–706; WebLevels of exposure associated with carcinogenic effects (Cancer Effect Levels, CELs) of tin compounds are indicated in Table 3-5 and Figure 3-5. ... six workers died 12 days following exposure to a mixture of half dimethyltin and half trimethyltin chloride vapor that occurred during the cleaning of a caldron at a chemical plant. Maximum exposure

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WebTrimethyltin-induced hippocampal neurodegeneration: A mechanism-based review 2016 Jul;125:187-99. doi: 10.1016/j.brainresbull.2016.07.010. Epub 2016 Jul 20. Authors Sueun Lee 1 , Miyoung Yang 2 , Jinwook Kim 1 , Sohi Kang 1 , Juhwan Kim 1 , Jong-Choon Kim 1 , Chaeyong Jung 3 , Taekyun Shin 4 , Sung-Ho Kim 1 , Changjong Moon 5 Affiliations

WebShowing 1-9 of 9 results for "trimethyltin" within Products. Products Genes Papers Technical Documents Site Content Chromatograms. Filter & Sort. All Photos (2) Trimethyltin chloride solution. Linear Formula: (CH 3) 3 SnCl. CAS No.: 1066-45-1. Molecular Weight: 199.27. Beilstein No.: 3535111. Compare Product No. Description SDS Pricing; 375187: ... WebMay 22, 2024 · Trimethyltin was first described as a potent nephrotoxicant in two studies where this compound was orally administered in rats (28, 41). TMT induced rats to a renal …

WebInstitute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing eﬀects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. WebOct 7, 2011 · TRIM24 is a potent liver-specific tumour suppressor in mice and attenuates RARα-mediated transcription. TRIM28 (also known as TIF1β and KAP1) is highly …

Weborganotins, such as trimethyltin and triethyltin compounds, can interfere with the way the brain and nervous system work. In severe cases, it can cause death. ... There is no evidence that tin or tin compounds cause cancer in humans. Studies in animals have not shown evidence of carcinogenicity for inorganic tin. A study in rats and another

WebOct 19, 2024 · Three aromatase inhibitors are currently approved in the United States for breast cancer treatment: anastrozole (Arimidex), exemestane (Aromasin) and letrozole … meigs county tn arrestsWebJul 1, 2024 · Trimethyltin chloride (TMT) is a by-product in the synthesis of organotin, a plastic stabilizer. With the rapid development of industry, the occupational hazards caused by TMT cannot be ignored. ... Cytotoxicity in vitro of compounds has been estimated on human cancer (colon cancer HCT-116, lung carcinoma A549, breast cancer MCF-7 ... meigs county tn circuit courtWebApr 6, 2024 · NiCl 2, a compound containing nickel, is extremely toxic to both humans and laboratory animals ( 1 ). Studies have shown that exposure to NiCl 2 is carcinogenic. NiCl 2 have the potential to cause cancer through various mechanisms, including oxidative stress, genomic DNA damage, epigenetic changes, and activation of transcription factors ( 2 ). meigs county tn building codesWebJun 16, 2010 · Trimethyltin chloride (TMTC) and triethyltin chloride (TETC) were fed to mallard (Anas platyrhynchos) ducklings for 73 to 75 d, beginning when ducklings were 3 to 4 d old. Diets were mixed to contain 0,0.5,5 or 50 ppm Sn as either TMTC or TETC. Mortality occurred only in the 5 ppm (2/5 ducklings) and 50 ppm (5/5 ducklings, all dying within 5 d) … meigs county tn building permitsWebAfter injecting TMT, animals show some behavioral changes such as seizures, aggressive behavior, self-biting, impaired working memory, and hyperactivity [4]. Studies show that TMT poisoning causes... nantwich fence repairsWebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. Like many other ototoxicants, it preferentially affects the outer hair cells of the basal (high-frequency) areas of the cochlea. Electrophysiological changes in the compound action potential can be detected within minutes. meigs county tn burn permitWebFeb 1, 2009 · Earlier experiments have shown that As2O3 and TMT modulate calcium signalling in tumour cells (human neuroblastoma, human cervix adenocarcinoma) as well as in non-tumour cells (human embryonic... meigs county speaks up