WebAug 1, 2008 · ... Because phosphorylation of ATG4B stimulates its activity, we elucidated the effect of TMED10 knockdown on ATG4B activity. Using a cell-based assay system wherein the proteolytic activity... WebHere, we find a protein translocation pathway regulating leaderless cargo entry into the vesicle carrier in UPS. We identified a transmembrane protein transmembrane emp24 domain-containing protein 10 (TMED10)/TMP21 as a regulatory factor for the secretion of multiple cargoes, including the mature form of interleukin 1(IL-1) family members and a …
Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B ...
WebMar 19, 2024 · TMED10-ATG4B interaction is diminished upon activation of autophagy. (A) SH-SY5Y cells transfected with pStrep- TMED10 and pHA-ATG4B were additionally treated with rapamycin (5 μM) for 3 h. The cells were harvested and subjected to immunoprecipitation using the indicated antibodies conjugated to Strep beads. The … WebMar 19, 2024 · The results suggest that the AD-associated protein TMED10 negatively regulates autophagy by inhibiting ATG4B activity. ABSTRACT Several studies have shown that dysfunction of macroautophagy/autophagy is associated with many human diseases, including neurodegenerative disease and cancer. To explore the molecular mechanisms … janiya brown funeral
A Novel Protein Encoded by Exosomal CircATG4B Induces Oxaliplatin
WebJul 29, 2024 · A recent paper in Cell identifies the transmembrane protein TMED10 as a protein channel for the vesicular translocation and secretion of mature IL-1β and other … WebFeb 18, 2024 · ATG4B is highly overexpressed in GCa clinical tumors and required for GCa cell growth. Our previous studies revealed that ATG4B is a potential therapeutic target in colon cancer [].This promoted ... WebMar 1, 2024 · Several studies have shown that dysfunction of macroautophagy/autophagy is associated with many human diseases, including neurodegenerative disease and cancer. To explore the molecular mechanisms of autophagy, we performed a cell-based functional screening with SH-SY5Y cells stably expressing GFP-LC3, using an siRNA library and … janiva magness i won\\u0027t be around