Tead4 cys367ser
Webb9 juni 2024 · First of all, TED-347 has an EC 50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. In addition, TED-347 specifically and covalently bonds with Cys-367 within … Webb21 apr. 2024 · The expression data of TEAD4 mRNA in glioma were collected from GEO database (GSE4290), and the expression of TEAD4 protein in glioma was confirmed …
Tead4 cys367ser
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Webb24 juni 2011 · TEAD4 is specifically expressed in developing skeletal muscle in mouse embryos. 1 Chromatin immunoprecipitation-array hybridization (ChIP-chip) showed that … WebbGal4 Tead4 Reporter Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
Webb15 aug. 2024 · Hydroxychloroquine, a chloroquine analogue used for malaria treatment, (i) down-regulated pro-inflammatory cytokine (e.g., IL-1β and TNFα) expression in … Webb29 nov. 2024 · Rewiring of the epigenome in therapy resistant cells also results in increased binding of the transcription factor TEAD4. Through interaction with TEAD4, VGLL1 induces the expression of genes implicated in cell proliferation in the resistant cells. We demonstrate that VGLL1 is necessary for the growth of fulvestrant-resistant breast …
Webbcomplex comprising TEAD4 and the transcriptional cofactors C-terminal binding protein 2 (CtBP2) and vestigial-like family member 4 (VGLL4). VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4–VGLL4–CtBP2 ternary complex dynamically existed at the early stage of adipogenesis. Finally, we ... Webb20 dec. 2024 · TEAD4 (217-434), TEAD4 (217-434) Cys367Ser mutant, and Yap1 (Full-length) were expressed as GST-fusion proteins in BL-21 (DE3) strain of E. coli from the …
Webb9 juni 2024 · In addition, TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a K i of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity. In the second place, TED-347 inhibits GBM43 cancer cell viability and inhibits co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged …
Webb19 feb. 2024 · EFTR 2, hRTEF 1B, RTEF1, TCF13L1, TEA domain family member 4, TEAD 4, TEAD4, TEF 3, TEF3, TEFR 1, Transcription factor 13 like 1, Transcription factor RTEF 1. PrimaryOrSecondary : Primary. AntibodyBuffer : PBS with 0.1% sodium azide and 50% glycerol pH 7.3. GenBankNo : gba runner 2 downloadWebb25 aug. 2024 · The ChIP-seq analysis of HHEX in HCT-116 cells identified 4697 peaks targeting 4381 genes (Supplementary Data 2 ). 767 genes were co-regulated by TEAD4 and HHEX in HCT-116 cells (Fig. 2h ).... days inn baltimore westWebb21 mars 2024 · TEAD4 (TEA Domain Transcription Factor 4) is a Protein Coding gene. Diseases associated with TEAD4 include Sveinsson Chorioretinal Atrophy and … g-bar ventures chicagoWebb21 apr. 2024 · ... wt hTEAD4 217-434 and Cys367Ser were cloned as previously described. 13,16For cellular Figure 4. Effect of the hTEAD4 Cys367Ser mutation on the YAP:TEAD4 interaction in cells. (A)... days inn bargain huber heightsWebbTEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [7] gba rubberized buttons walkthroughWebbTEAD4 Antibodies. Antibodies that detect TEAD4 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, … days inn bardstown kyWebbTED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of … days inn baltimore south glen burnie