Sterically stabilized liposomes
網頁Sterically stabilized liposome-containing PTX (PTX-SSL) was prepared by a similar procedure, except that the DSPE-PEG-H 7 K(R 2) 2 replaced by DSPE-PEG and 5% glucose solution was used as the hydration medium. The preparation of … 網頁2002年6月1日 · These are small (~100 nm) and rigid liposomes, onto which a polymeric coat of polyethylene glycol has been grafted. These pegylated (also referred to as sterically stabilized or 'Stealth') liposomes display inhibited interaction with plasma proteins and mononuclear phagocytes, and they consequently display greatly prolonged circulation time.
Sterically stabilized liposomes
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網頁reports of sterically stabilized liposomal dox and greatly supe-rior to those of “conventional” liposomes (27). Direct comparison of anti-HER2 immunoliposome-dox versus sterically stabilized liposomal dox prepared identically except for … 網頁2008年9月28日 · The stable encapsulation of the doxorubicin in an aggregated form also permits freezing and lyophilization of the liposomes with only minimal drug release. The loading by ammonium sulfate gradient approach meets all pharmaceutical requirements; it has brought the clinical use of DXR-loaded sterically-stabilized liposomes to reality. …
網頁2013年2月22日 · Liposomes were successfully used in site-specific targeting in anticancer therapy [46]. In this study, Chla loaded in the biomimetic membranes was used as a spectral biosensor to investigate the... 網頁This paper describes the hydrolysis rates, contents release rates, and fusion kinetics of BVEP-stabilized DOPE liposomes at 1:99, 3:97, and 5:95 molar ratios of BVEP/DOPE. …
網頁2015年3月31日 · Experiments with PBCEC showed that sterically stabilized (PEGylated) liposomes without protein as well as liposomes conjugated to native bovine serum albumin (BSA) were not taken up. In contrast, cBSA-liposomes were taken up and appeared to be concentrated in intracellular vesicles. 網頁1996年2月1日 · Sterically stabilized liposomes. M. Woodle, D. Lasič Biology, Chemistry Biochimica et biophysica acta 1992 1,047 Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. A. Gabizon, R. Catane, +6 authors Y. Barenholz Medicine, Biology …
網頁1992年4月1日 · Sterically stabilized liposomes. Reduction in electrophoretic mobility but not electrostatic surface potential Author links open overlay …
網頁1995年9月1日 · Sterically stabilized liposomes, ones modified at the surface with hydrophilic polymers (PEG), have proven to reduce in vivo recognition and … buggy and buddy kaleidoscope網頁2010年11月20日 · Liposomes are widely investigated for their use as drug delivery systems, where they have to meet strict stability criteria. Hence, it is of common interest to … crossbow 470 fps網頁2008年9月28日 · Abstract We investigated the intrahepatic distribution in rats of liposomes of 85 or 130 nm diameter, which were sterically stabilized with a polyethylene glycol) derivative of phosphatidylethanolamine (PEG-PE) so as to increase their circulation time in blood. Various ... buggy and buddy paper strip angel網頁1997年1月24日 · These “sterically stabilized,”; or “Stealth®,”; liposomes were successfully used for the treatment of experimental cancers in vivo ( 8, 9, 10 ), and liposomes … crossbow 600 fps網頁2015年5月29日 · Liposomes are artificially prepared lipid vesicles containing an internal aqueous phase. Their characteristics, which include flexibility of composition, biocompatibility, biodegradability and non-immunogenicity, make them suitable for … crossbow 450 fps網頁2024年11月1日 · Sterically stabilized liposomes have been prepared using the ethanol injection solvent evaporation method. Lipid excipients containing HSPC/CH/ mPEG2000 … buggy and buddy crafts網頁2024年3月8日 · Numerous polymers have been used to increase the stability of the liposome in blood vessels by forming a polymeric barrier on the surface of liposome. This polymer-mediated protection is also described as “steric stabilization” (Torchilin 2012 ). buggy and buddy rocket