Web10 Dec 2024 · This article summarizes the evolution of the screening deck at the Novartis Institutes for BioMedical Research (NIBR). Historically, the screening deck was an … Web14 Apr 2024 · Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E...
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Web12 Apr 2024 · Any of the following abnormal laboratory values at Screening or pre-dose Day 1 assessment: Hemoglobin levels below 8.0 g/dL at screening Eosinophil count >700 mm3 or >2 X Upper Limit of Normal (ULN), whichever is lower. - History of capillary leak syndrome (CLS). Other protocol-defined inclusion/exclusion criteria may apply Study Location … WebMBG453 (sabatolimab) is an anti-TIM-3 monoclonal antibody being studied for the treatment of higher-risk myelodysplastic syndromes and acute myeloid leukemia, both rare blood … nazar latest news gossip
Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase …
Web12 Apr 2024 · This is a randomized, double-blind, placebo-controlled, multicenter, Phase II study evaluating the efficacy and safety of ociperlimab in combination with tislelizumab and chemotherapy as first-line treatment for participants with advanced TNBC whose tumors express PD-L1 (CPS ≥ 10). WebThe Novartis Performance Management Process is one of the key business processes that help Novartis achieve sustained success of its business in a rapidly changing and increasingly competitive market. The process drives a performance culture by setting … Web1 day ago · LVEF ≤ 50% documented at screening Systolic blood pressure 110 - 160 mmHg (cohort 1) or 105-160 mmHg (cohort 2), and heart rate between 50-90 beats per minute, inclusive Treatment with a stable dose of a beta blocker. Cohort 1: Treatment with a stable dose of ACE inhibitor or ARB Cohort 2: Treatment with a stable dose of sacubitril/valsartan. nazar latheef