WebJan 1, 2024 · Phospholemman (PLM) is a 72-amino-acid type I single-span membrane protein, belonging to the FXYD (pronounced “fix-it”) family of ion transport regulators. These smallmembrane proteins are tissue-specific regulators of the Na/K ATPase (Na/K pump or … WebOct 27, 2006 · Phospholemman (PLM) or FXYD1 is a major cardiac myocyte phosphorylation target upon adrenergic stimulation. Prior immunoprecipitation and functional studies suggest that phospholemman associates with the Na/K-pump (NKA) and mediates adrenergic Na/K-pump regulation.
FXYD1 (Phospholemman) SpringerLink
WebPhospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. WebAug 8, 2002 · In the present study, we demonstrate that phospholemman (PLM) (FXYD1), so far considered to be a heart- and muscle-specific channel or channel-regulating protein, associates specifically and stably with six different α-β isozymes of NKA after coexpression in Xenopus oocytes, and with α1–β, and less efficiently with α2–β isozymes, in ... psg boys tracksuit uk
Phospholamban - Wikipedia
Web13721-1-AP targets Phospholemman/FXYD1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. WebApr 1, 2009 · Phospholemman and the Na/K ATPase in the diseased heart Not only is the activity of the Na/K ATPase crucial for the maintenance of the normal trans-membrane Na gradient in the healthy heart, but there is increasing evidence that perturbation of this gradient may also play a crucial role in the pathophysiology of ischaemia/reperfusion [19•, … WebAug 18, 2010 · Phospholemman (PLM), a member of the FXYD family of regulators of ion transport, is a major sarcolemmal substrate for protein kinases A and C in cardiac and skeletal muscle. In the heart, PLM co-localizes and co-immunoprecipitates with Na + -K + -ATPase, Na + /Ca 2+ exchanger, and L-type Ca 2+ channel. horse transportation services in colorado