WebApr 24, 2013 · Furthermore, intravenous injections of PEG 400 in Hannover Wistar rats caused increased serum sodium, decreased serum lactate, increased free fatty acids (FFAs), increased aspartate aminotransferase, and increased glutamate dehydrogenase. 3 The PEG 400 also produced an antidiuretic effect, an antisaluretic effect, an increased urine … WebThe partition coefficient of PEG 400 between hexane and water is 0.000015 (log =), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of …
Polyethylene glycol 400 (PEG400) affects the systemic exposure …
WebWhat is PEG-400 used for? PEG-400 in personal care: It serves as the base for skin creams and lotions and acts as a solubilizer in creams, lotions, and bath gels. It also works as a … WebI have to inject mice intraperitoneally a dose of 300mg/kg. The best vehicle so far is : EtOH : PEG400 : SALINE (1 : 6 : 3). I am concerned about the high PEG concentration. I have tried … night music song
Tolerable Levels of Nonclinical Vehicles and Formulations Used in ...
WebDec 15, 2013 · When administered ip at a high dose to mice without prior dilution, PEG-400 has an apparent cytopathic effect on mesothelial cells and hepatocytes immediately … Weba. Intraperitoneal (IP) injections should be made into the animal’s right abdominal quadrant so as to avoid penetrating the cecum on the left side. b. Please refer to the Guidelines for Injections in Rodents and Rabbits, Virginia Tech Office of the University Veterinarian for recommended volumes and needles sizes. II. Weband female CD-1 and C57BL6 mice (5-7 weeks old, 25–35 g at study start) that had received a single ip injection of PEG-400 (density: 1.126 g/mL) at 4 mL/kg of body weight. Animals had been killed with a raising concentration of carbon dioxide, followed by exsanguination by cardiac puncture at 1, 5, 8 or 24 h post treatment. nrotc host schools