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Gsea autophagy

WebApr 11, 2024 · The GEO30122 dataset was examined using GSEA to characterize the functional genome associated with diabetic nephropathy. Finally, a total of 226 datasets met the FDR Q value <0.25 and the p. adjust value <0.05. We selected 14 of these pathways that met NES ≥ 2.0 and the adjusted p-value < 0.05 for GSEA enrichment analysis to be … WebNov 10, 2024 · The Gene Set Enrichment Analysis (GSEA) showed that the gene sets related to autophagy are significantly differentially expressed among the paired normal tissues and RCC. Multivariate and univariate Cox analyses were used to construct the gene signature related to prognosis.

REACTOME_CHAPERONE_MEDIATED_AUTOPHAGY - GSEA

WebApr 10, 2024 · The Coatomer protein complex Zeta 1 (COPZ1) has been reported to play an essential role in maintaining the survival of some types of tumors. In this study, we sought to explore the molecular characteristics of COPZ1 and its clinical prognostic value through a pan-cancers bioinformatic analysis. We found that COPZ1 was extremely prevalent in a … WebDec 17, 2024 · Keywords: GSEA; autophagy; gene signature; glioblastoma; prognostic model. Publication types MeSH terms Autophagy / genetics Autophagy / physiology* Databases, Genetic Gene Expression Regulation, Neoplastic Genetic Testing* Glioblastoma / metabolism* Glioblastoma / pathology* Humans Nomograms* Prognosis Reproducibility … ch125 elite https://paulasellsnaples.com

The lnc-CTSLP8 upregulates CTSL1 as a competitive …

WebThe GSEA analysis results show that ribosomal biological processes and photosynthesis-related pathways are obviously enriched in the three stages, and photosynthesis-related pathways are the main biological processes with down-regulation in the three stages. ... Besides, we discovered that the autophagy and the RNA degradation process was ... WebJul 8, 2024 · In addition, we recently found that mTOR is involved in the regulation of autophagy and muscle protein degradation under hypoxic conditions (Chen et al., 2024). It is essential to investigate the effects of mTOR on muscle cells to gain a better understanding of myogenesis. ... GSEA Showed Enriched Among Differentially … WebCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): … ch127 urrea

RNA-seq and GSEA identifies suppression of ligand-gated ... - Nature

Category:GSEA MSigDB

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Gsea autophagy

KEGG_REGULATION_OF_AUTOPHAGY - GSEA MSigDB

WebSep 2, 2024 · The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature. WebThe seven autophagy-related signatures predicted the OS of patients with RCC correctly, exhibiting a significant potential for clinical applications, including custom prediction and …

Gsea autophagy

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WebMar 23, 2024 · Optineurin (OPTN) is a conserved protein that has been identified as an autophagy receptor and plays a central role in selective autophagy. It has been reported that OPTN, as a receptor, is generally recruited into ubiquitin-coated depolarized mitochondria and has been shown to be a major molecule necessary for mitophagy ( … WebDec 2, 2024 · Autophagy is a biological process that has been extensively involved in the progression of tumors. Long noncoding RNAs (lncRNAs) have been discovered to be critical in diagnosing and predicting various tumors. ... Gene set enrichment analysis (GSEA) revealed that the three DEARlncRNAs were significantly enriched in CCA-related …

WebAug 19, 2024 · GSEA analyses revealed that autophagy-related biological processes are enriched in low-risk groups. Conclusions: Autophagy-related genes and lncRNAs are differentially expressed between stage 4 and … WebOct 21, 2024 · Identification of Autophagy-Related Messenger RNAs in Neuroblastoma. A total of 694 autophagy-related encoding genes were obtained from the Human Autophagy Database (HADb 5) and the Molecular Signatures Database of Gene Set Enrichment Analysis (GSEA 6). Next, 643 ATG mRNAs were identified by mRNAs of the training …

WebMar 3, 2024 · If you have a question, see the FAQ or the User Guide. The User Guide describes how to prepare data files, load data files, run the gene set enrichment analysis, and interpret the results. It also includes instructions for running GSEA from the command line and a Quick Reference section, which describes each window of the GSEA desktop … WebAug 13, 2024 · Autophagy has been associated with oncogenesis with one of its emerging key functions being its contribution to the metabolism of tumors. ... GSEA was performed using GSEA v3.0 tool developed by ...

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WebAug 13, 2024 · Autophagy has been associated with oncogenesis with one of its emerging key functions being its contribution to the metabolism of tumors. ... GSEA was performed … hannas bookshopWebApr 12, 2024 · Terms such as autophagy (GO:0006914) process utilizing autophagic mechanism (GO:0061919), positive regulation of autophagy (GO:0010508), and autophagosome assembly (GO:0000045) were suppressed in GSEA (Fig. 3A). These results suggest that thrombin may reduce cholesterol efflux by affecting lipid hydrolysis … hannas bakery and cafeWebGene set enrichment analysis (GSEA) To uncover the hidden functions of the feature genes, GSEA software (version 4.4.3) was used. Analyzes were conducted on two subsets of the Molecular Signatures Database (MSigDB), c5.go.bp.v7.4.symbols.gmt for GO and c2.cp.kegg.v7.4.symbols.gmt for KEGG. ... In support of our findings, the autophagy ... hanna schilling trierWebAug 11, 2024 · Gene set enrichment analysis (GSEA) ... Autophagy alleviates oxidative stress by eliminating damaged mitochondria and ROS in a process called mitophagy . To investigate if autophagy activity was different in TAM subsets in response to high OXPHOS, we treated macrophages with chloroquine (CQ), an autophagy inhibitor, to prevent … hanna rothmanWebJan 8, 2024 · The autophagy gene list was obtained from human autophagy database . The gene candidates in this database have been reported to directly or indirectly involve in autophagy. Through a GSEA, autophagy was found to be significantly enriched in the high-DDIT4-expression group (Fig. 6A). ch-124 sea kingWebFor the Mouse gene set with the same name, see GOBP_SELECTIVE_AUTOPHAGY. Standard name. GOBP_SELECTIVE_AUTOPHAGY. Systematic name. M24317. Brief description. The macroautophagy process in which specific structures are targeted by the autophagy process. [PMID:20484971, PMID:21997368, PMID:22966490] hannas bakery stillwaterWebNov 12, 2024 · GSEA can analyze the probe identifiers or collapse each probe set to a gene vector, where the gene is identified by gene symbol. Collapsing the probe sets prevents … ch 128 bankruptcy wisconsin