Carboxymethylproline
WebOct 14, 2005 · CarB catalyzes formation of (2 S ,5 S )-carboxymethylproline [ (2 S ,5 S )- t -CMP] from malonyl-CoA and l -glutamate semialdehyde. In addition to using a cosubstrate, CarB catalyzes C-C and C-N bond formation processes as well as an acyl-coenzyme A hydrolysis reaction.
Carboxymethylproline
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WebThe biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the … WebCarboxymethylproline synthase was shown to condense L-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of D-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA. Publication types Evaluation Study Research Support, Non-U.S. Gov't
WebCarboxymethylproline synthase Gene carB Status UniProtKB reviewed (Swiss-Prot) Organism Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. … WebOct 14, 2005 · Formation of carboxymethylproline (t-CMP) 2 the β-amino acid precursor of the first formed β-lactam ((3S,5S)-carbapenam-3-carboxylate) is catalyzed by a member …
WebCarB catalyzes formation of (2 S ,5 S )-carboxymethylproline [ (2 S ,5 S )- t -CMP] from malonyl-CoA and l -glutamate semialdehyde. In addition to using a cosubstrate, CarB … WebStereoselective C C bond formation catalysed by engineered carboxymethylproline synthases. Christopher Schofield Refaat Hamed. 2011, Nature Chemistry. The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting …
WebCarboxymethylproline synthase was shown to condense l-glutamate semialdehyde with malonyl-coenzyme A to produce (2S,5S)-carboxymethylproline, while incubation of d-glutamate semialdehyde results only in uncoupled turnover of malonyl-CoA.
WebRole of carboxymethylproline synthases in carbapenem biosynthesis and CarB engineering. (A) Biosynthesis of the simplest carbapenem as catalyzed by the crotonase … download uhd graphics 630 30.0.101.1404WebEnzyme in action: Labeling studies and the finding that carboxymethylproline synthase catalyzes production of deuterated (2S,5S)-6,6′-dimethyl-trans-carboxymethylproline (3) from dimethylmalonyl-CoA (1) and labeled l-pyrroline-5-carboxylate (2) limit possible mechanisms of C C bond formation and thioester hydrolysis. download uhc minecraftWeb(2S,5S)-5-Carboxymethylproline C7H11NO4 CID 447989 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … clay based wallpaper adhesiveWebOct 9, 2013 · Engineering carboxymethylproline synthases to accept malonyl-CoA 1 analogues with bulky side chains. (A) CarB and ThnE catalysed synthesis of (2 S ,5 S )carboxymethylproline 3 ; 7,10 (B) A view... clay bashonioWebJun 13, 2005 · Generic Name (2s,5s)-5-Carboxymethylproline DrugBank Accession Number DB03215 Background Not Available Type Small Molecule Groups Experimental … clay based toothpaste wintergreenWebFeb 1, 2004 · Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the … clay basin and washclothWebCarboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carbapen-2-em-3-carboxylate, the simplest member of the carbapenem family of β … clay basin storage